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Even when all included studies would have been methodological well designed, indication bias remains a threat to validity in observational studies.
For example, the Pfizer's Viagra and Celgene's thalidomide are both successful examples that are used to treat new application rather than the designed indication during the development stage [ 2- 4].
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A control chart is designed for indication of warning and action limits of the determination results and for diagnoses of outliers in the further titrations.
Also, the effects of the combinations of these characteristics is used to draw precious design indications.
By improving the approach to pediatric study design, indications for pediatric-specific therapies can be developed.
Finally, some mortar mix design indications are proposed according to extrusion criteria based on rheological conditions.
Further modifications in the design, indications, or technique may be necessary to improve outcomes of this unicompartmental knee arthroplasty system.
Finally, some numerical simulations are performed with non-linear finite element models and some useful design indications are given.
Because of the novelty of the FRCM technique and the wide spectrum of FRCM materials (both grouts and grids) present on the market, no design indications are now available for such a strengthening technique, for both concrete and masonry elements.
Applying it, useful design indications can be derived also by varying simple parameters using thermal and physical data easy to get.
Nevertheless, there is a lack of both experimental information and specific design indications in technical codes on this type of construction.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com