Exact(60)
He quickly designed compounds based on the genetic sequence.
The designed compounds were synthesized and evaluated.
The designed compounds showed potent antifungal activities with broad spectrum.
BDEs of all designed compounds are larger than 20 kcal/mol shows that all designed compounds have a reasonable thermal stability.
Interestingly, some of the designed compounds displayed wonderful fungicidal activities in vivo against cucumber Pseudoperonospora cubensis.
The minimal EC50 values of designed compounds against Xanthomonas oryzae pv.
Therefore, the designed compounds effectively inhibited both invasive ductal breast carcinoma and bone metastasis.
The designed compounds demonstrated low to moderate cytotoxicity in several cell lines.
The molecular docking study of compound 2b further supported the molecular basis of the designed compounds.
The newly designed compounds were synthesized on the trails of ketoconazole using the molecular hybridization approach.
Molecular dynamics simulations show that the designed compounds have interaction profiles similar to partial agonists.
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