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Another unique feature of our study is that we designed candidate helper T cell vaccine targets specifically to the Chinese population.
Based on these data, the dose of 300 nmol/l siRNA was used in further experiments to screen the designed candidate siRNAs.
Recently, genome-wide association studies (GWAS) and carefully designed candidate gene approaches have determined that the FOXE1 genetic variant, which is downstream of the TSH-cAMP pathway, is the suspected risk factor for follicular-cell-derived thyroid cancer [ 42- 44].
We used high density peptide array analysis to identify regions in TDP-43 that are bound by TDP-43 itself and designed candidate peptides that might be able to reduce TDP-43 aggregation.
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Among the designed candidates, –NO2 substituted BTA (BTA8) is promising with an absorption maximum at 647 nm.
We observed good overall success rate, with the notable exception of very low targeted GC-content (10%), and a good to excellent entropy within designed candidates.
Five 21- to 23-nt long sequences (Table 1) were identified from the rat MMP2 mRNA [GenBank: NM_031054] for designing candidate shRNA constructs (designated shMMP2a-e).
This work may supply a new environmental friendly and type II heterostructure nanocrystals to design candidate materials for hybrid photovoltaic devices.
This study used Marxan software to design candidate MPA networks to meet conservation targets for 67 coastal fish species on the east coast of South Africa.
Here, a computational approach has been employed to design candidate water compatible visible light photosensitizers which could improve the photo-polymerization of the hydrophilic-rich phase.
Findings will be used to design candidate interventions with the aim of encouraging multimorbid patients and their informal carers to become more actively involved in condition management.
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