Sentence examples for designed by substituting the from inspiring English sources

A set of push pull oxazolone derivatives have been designed by substituting the 2-phenyl-4-benzylidene-1,3-oxazol-5-one unit in two different positions with a combination of electron donor (dimethylaniline) and/or acceptor (nitro, nitrile and benzimidazole) groups.

The trapped human CXCL8 monomer (L25NMe) was designed by substituting the dimer interface residue Leu-25 with N-Methyl Leu, which disrupts H-bonding interactions and introduces steric bulk about the two-fold symmetry point [10], [11].

As a result, the AEXynM was designed by substituting the N-terminus of AuXyn11A with the corresponding one from Asn to Arg of EvXyn11TS.

The DOPA-containing DOPA DOPA and Fmoc DOPA DOPA building blocks were designed by substituting the phenylalanines in the well-studied diphenylalanine self-assembling motif and its 9-fluorenylmethoxycarbonyl (Fmoc -protected derivative.

For determining the crucial amino acids in the replaced N-terminus that contributed to the high thermostability of AEXynM, 20 hypothetic single mutant xylanases were designed by substituting the N-terminal of various amino acids of AEXynM with the corresponding ones of AuXyn11A, respectively.

As an alternative strategy for direct pol II expression of shRNA, artificial miRNA scaffolds incorporating siRNA targeting luciferase or ApoB were designed by substituting the mature miRNA sequence with luciferase and ApoB target sequences, resulting in CMV-miLuc, CMV-miApoB1 and CMV-miApoB2.

Herein, sixteen mutants were designed by substituting these residues with Ala.

The APL has been rationally designed by substituting two of the critical residues for recognition by the T-cell receptor.

The derivatives of Compound 2 used in the experiment (H2-38, H2-74, H2-81 andesigned were designed by substituting functional groups while keeping the core thiazolidione structure intact.

In the experiments, three different concrete compositions were designed by substituting natural coarse aggregates with recycled coarse aggregates at the replacement ratios of 0%, 30%and50%0%and50%

Anion-selective ionophores have been designed by substituting urea and thiourea group containing chains to the hydroxyl linkers of chenodeoxycholic acid frames; their selectivity closely followed the sequence of Hoffmeister series, except the unusually large response of the thiourea-substituted ionophore to sulfate.