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UKPDS was designed as a monotherapy study.
The Tamoxifen Exemestane Adjuvant Multinational (TEAM) trial was originally designed as a monotherapy comparison of 5 years of examestane versus tamoxifen.
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Our trial, LEAD-3, was designed as a parallel-group, head-to-head monotherapy trial evaluating the 2-year safety and efficacy of liraglutide (1.2 and 1.8 mg) compared with glimepiride 8 mg.
The interchange is designed as a trumpet.
TPM, which was originally designed as an oral hypoglycemic agent [ 3], was found to be an effective and tolerable antiepileptic drug, both as monotherapy and as add-on, in children and adults [ 4].
"It was designed as an ultraflat watch.
Nevertheless, the study by Lam et al. contained unexpected high heterogeneity, and included RCTs that designed rTMS as either monotherapy or augmentation to antidepressants, which may be on suspicion of mixing studies of great heterogeneity together.
Only tocilizumab has been repeatedly demonstrated to be superior as a monotherapy over MTX or other csDMARDs, although the Japanese study had an oplen label design and the MTX dose was low.
Byetta is currently approved for use alongside other diabetes drugs, and Lilly and Amylin have asked the F.D.A. to approve it as a monotherapy as well.
However, EGFR inhibition as a monotherapy, as with the monoclonal antibody cetuximab, is ineffective.
High-dose-rate (HDR) brachytherapy as a monotherapy is appealing, but its use is still investigational.
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CEO of Professional Science Editing for Scientists @ prosciediting.com