In this paper, we have designed and characterized substituted, tricyclic Jak3 inhibitors that selectively avoid inhibition of the other JAKs.
In this study, we designed and synthesized substituted hexa-2,4-diyne-1,6-diols hexa-2,4-diyne-1,6-diols hexa-2,4-diyne-1,6-diols hexa-2,4-diyne-1,6-diols hexa-2,4-diyne-1,6-diolsevaluated their cancer chemoreeventive activitiestructurallyng concentration of doubling quinone reductasimplifiedy (CD), cell viabilitunable chemopreventive index (CI).
Here, we designed and synthesized three substituted cyclopropane derivatives that occupy all available pockets of sEH catalytic domain.
A series of naphthalimide derivatives were designed and synthesized by substituting electron-donating phenoxy groups at the 4th position of 1,8-naphthalimide.
Based on a molecular modelling approach we designed and synthesized novel C15-substituted estrone derivatives.
We designed and synthesized novel N-substituted 7-azaindoline derivatives as selective M1 and M4 muscarinic acetylcholine receptors (mAChRs) agonists.
We have designed and synthesized two alkylthio substituted benzothiadiazole-quaterthiophene based conjugated polymers (P1 and P2) and investigated their photovoltaic performances.
Based on our hypothesis that the 3,3-diphenylpentane (DPP) skeleton is useful as a multi-template for creation of various biologically active compounds and acts as a steroid skeleton substitute, we designed and synthesized novel HMG-CoA reductase inhibitors with a DPP skeleton.
A series of novel antitumor and DNA photocleaving agents was designed and synthesized by fusing a (substituted) thiazole ring to the naphthalimide skeletons.
In our efforts to discover more potent and lasting NHE1 inhibitors, we designed and synthesized a series of substituted indan-1-ylidene aminoguanidine derivatives (5).
