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The single-chain salmon MHC class I molecule has been designed and generated, in which the carboxyl terminus of β2m is joined together with a flexible 15 or 20 amino acid peptide linker to the amino terminus of the heavy chain (Sasaβ2mUBA*0301).
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MJF participated in the design of the statistical approach and performed statistical analysis using R. RWF designed and generated the in silico masking approach.
Several groups have designed and generated RNAi reagent libraries for studies in cells or in vivo for Drosophila and other species.
As the number of experimentally characterized lipid structures constitutes only a small fraction of the number of possible structures that may exist in nature (Gross and Han, 2011; Shevchenko and Simons, 2010), the curated knowledge available in SwissLipids was used to design and generate an in silico library of feasible lipid structures for selected common lipid categories.
We went on to design and generate inversions in various regions of the genome, tagging the inversion with a mouse coat color gene.
GNW was designed for generating in silico benchmarks of gene expression profiles by extracting network modules from prior in vivo studies (such as S. cerevisiae[ 38, 39]) and connecting/expanding these modules to form test networks.
The visual tensions between space and surface design generated in those works make them among the most austere creations of the artist's career, but they also possess a splendour and finality that rank them among the very greatest masterpieces of Classical art.
A major challenge of the proposed approach was reduction of semantic gap between design documents and CAD models because design documents generated in the early design stage contain abstract design descriptions, while CAD models contain detailed design descriptions.
And sometimes the designs generated in a competition prove beyond the client's means, and the project is jettisoned altogether.
Using these factorial designs as bases, more and larger supersaturated designs can be generated in a systematical procedure.
We design and generate the attacks in a real network setup and report the results.
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