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To test this hypothesis, we designed a library of artificial amphiphilic peptides based on the sequence (FEFEFKFK 2 by substituting combinations of the non-polar residues glycine, alanine, valine, leucine and isoleucine for phenylalanine.
In this study, we designed a library of compounds based on the structures of well-known ligands of the 18 kDa translocator protein (TSPO), one of the putative components of the mPTP.
In order to discover novel probes that may help in the investigation and the control of bacterial biofilms, we have designed a library of triazole-based analogs of 2-aminoimidazole marine alkaloids: naamine A and isonaamine A. Twenty-two compounds were screened for their biofilm inhibitory activity against two strains of Gram-negative bacteria.
De Luca et al. (2006) designed a library of 14 cyclic CCK8 analogs, based on the structural details of the complex between CCK8 and the CCK2 receptor fragment.
We designed a library of peptide substrates that could be used to identify whether PCAF interacts with H3 residues distal to the Lys14 acetylation site.
Given the different enzymatic activities found in CAM1 and CAM2, and starting from the sequence of CAM1, we designed a library of truncated variants.
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C-Galactosides have been used as scaffolds to design a library of non-hydrolysable inhibitors of cholera toxin (CT).
Protein evolution relies on designing a library of sequences that capture meaningful functional diversity in a limited number of protein variants.
For the construction we used the interpolatory discrete splines which enabled us to design a library of perfect reconstruction filter banks.
The functionality maps are also used to design a library of disubstituted indoles that might prevent the binding of the protein substrates.
This setback served as an impetus for rationally designing a library of next-generation antibiotics that exhibit a bactericidal effect on resistant P. acnes and exert an immunomodulatory function to reduce inflammation.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com