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However, designation of the negative class can be problematic and if it is not properly done can affect the performance of the classifier dramatically and/or yield a biased estimate of performance.
A designation of 'negative for malignancy' was considered a negative result.
The early designation of an Otx2-negative, Hoxa2-negative region, prior to the appearance of the isthmic organiser, is a key initial step in the specification of the cerebellum.
It should be noted that STAT6 was frequently and highly expressed in vascular endothelial cells surrounding blood vessels seen in the specimens; however a designation of positive or negative was used to refer exclusively to STAT6 expression in tumor cells.
Cultures were checked for the presence of B. burgdorferi by dark-field microscopy for up to 8 weeks after which a final designation of positive or negative was assigned.
For both biomarkers, we used an H-score ≥1 as a cut-off for designation of positive or negative status in accordance with the American Society of Clinical Oncology/College of American Pathologists guidelines for ER and PgR positivity [ 20].
What we do know, however, is that the inconsistencies in designation of genes as positive or negative in their regulatory influence reflect uncertainties and context-dependent relationships in the field.
The presence of the fusion protein in ARMS has led to the designation of fusion-positive vs fusion-negative RMS.
The designation of 'nonallergic' is applied when the allergy examination, including history, skin-prick testing, and serum-specific IgE measurements, is negative.
The designation of Pakistan is itself elusive.
The designation of his new casting dawns on him slowly.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com