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Targets with currently registered therapeutics for the phenotype of interest which were not predicted by Gentrepid but present in the search space were designated "false negatives".
The data were also analyzed using Pathway Studio (Ariadne Inc., Rockville, MD) to generate gene lists with designated false discovery rates (FDR) (Reiner et al. 2003).
Targets which were not predicted by Gentrepid, but present in the search space and targeted by currently registered therapeutics for the CAD, were designated "false negatives".
If cell was identified as high risk after date of onset of illness, or cell was never identified as high risk and a case occurred within it, it was designated false negative (yes/no).
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Last year, the military amplified the 2007 law by providing grounds for the government to prosecute anything they designate as "false," "partially false," or "distorted" information, a determination that the government itself gets to make.
When an alternative diagnosis was established, these cases were designated as false negatives.
These 48 compounds were designated as false positives and eliminated from further evaluation.
Each of the new entries is examined manually and either added to the database or designated as false positive.
Ontario infants confirmed to have MCADD had markedly elevated C8 levels compared to those designated as false positives (median C8 levels of 8.93 uM versus 0.47 uM respectively), including those determined to be heterozygous mutation carriers (median C8 level of 0.5 uM).
Apart from differences in tissues, their analysis was carried out on two independent RNA pools from three to five animals for each experimental condition, thereby preventing statistical analysis of intra-group variation and they may have identified genes that in our analysis would be designated as false positives.
If the proportion misclassified as false-positive were twice the rate observed among those designated as false-positive with follow-up testing, the false-positive rate among non-pregnant persons would be higher than 0.15%, the false-positive EIA rate among pregnant women based on this sensitivity analysis.
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