Previous reports designated BEIIb-deficient mutants in maize and rice as amylose-extender (ae) mutants, in which the abundance of short amylopectin chains was reduced (Kim et al. 1998; Nishi et al. 2001).
Sequence analysis of the HER2+ brain metastases revealed no pathogenic mutations of BRCA1, and therefore the aforementioned signature was designated BRCA1 Deficient-Like (BD-L).
To assess if S1P1 plays a role in immature-B cell egress from the BM we analyzed the distribution of developing B cells in BM parenchyma and sinusoids, peripheral blood and spleens of mice in which S1P1 was conditionally ablated in B-lineage cells (hereafter designated as S1P1-deficient).
These tumors are designated as SDH-deficient GISTs or SDHB-negative GISTs based on their immunohistochemical (IHC) status.
B6.129P2-Tcrbtm1MomTcrdtm1Mom (designased as T cell deficient mice), BALB/c and B6 Act-mOVA mice were purchased from the Jackson Laboratories, Bar Harbor, ME.
Transgenic expression of CD94 in these CD94-deficient mice (designated CD94Tg/– mice) restored expression of CD94-NKG2A, CD94-NKG2C, and CD94-NKG2E (Fig. 1A).
First, we established SW1990 stable cell lines ectopically expressing wild-type FBW7 and a T205A phospho-deficient mutant, designated as SW1990/FBW7WT and SW1990/FBW7T205A respectively.
UBIAD1-deficient cells (designated UBIAD1−) were generated as follows: on day 0, SV589 cells were set up at a density of 7 × 10 cells per 100-mm dish in medium A supplemented with 10% FCS.
NF is an original breeding line from SES Vanderhave and was used to generate a GA-deficient line designated 2210 (Mutasa-Göttgens et al., 2009) which was used as a control for monitoring the potency of the applied GA4 solutions.
In all experiments described in this study we used previously reported mice transgenic for HLA-DR1 on a major histocompatibility complex (MHC) class II-deficient background (designated C57BL/6J0-0 HLA-DR1), whicarriedied full-length genomic constructs for HLA-DRA1*0101 and HLA-DRB1*0101, developed by one of us (DMA) [ 27].
