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STUDY DESIGN: We identified women in a database of commercial insurance beneficiaries who underwent cesarean delivery and who were opioid naive in the year prior to delivery.
Using structure-based drug design, we identified a novel series of 5,6-dihydroimidazolo[1,5-f]pteridine 5,6-dihydroimidazolo[1,5-f]pteridine 5,6-dihydroimidazolo[1,5-f]pteridine
Through iterative synthesis and analog design, we identified compounds with improved biochemical RORc inverse agonist activity and RORc cellular potencies.
Study design: We identified 66 case reports and case series of delayed interval delivery published between 1880 and 2002.
Using parallel synthesis supported by structure-based drug design, we identified peptidemimetic FVIIa/TF inhibitors (compounds 4 11) containing l-Gln or l-Met as the P2 moiety.
Study design: We identified a population of 193 infants who met our case criteria for CLD whose birth weights were ≤1500 g.
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Utilizing a systematic methodology for catalyst design, we identify Ir@Pt (core@shell) nanoparticles as a promising system for enhanced ORR performance, synthesize Ir@Pt core-shell nanoparticles, and demonstrate an activity and stability enhancement over the commercial state-of-the-art Pt/C catalyst.
Using an advanced intercross mapping design, we identify three autosomal QTL contributing to the difference in lobe shape between a pair of D. melanogaster inbred lines.
Using a case-control design, we identify two SNPs in complete linkage disequilibrium near the start of transcription of the GH1 gene that may predispose to reduced birth weight.
We list the best designs we identified to accommodate 4⩽k⩽9 experimental factors.
From 103 designs, we identified one, named DS-SOSIP.4mut, with four additional mutations at the interface of potentially mobile domains of the prefusion-closed structure.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com