Sentence examples for design trial that from inspiring English sources

In contrast, an adaptive design trial that employs limited flexibility, and is an adequate and well-controlled investigation, has a greater power gain than a fixed design trial, in which the genomic biomarker is capable of predicting treatment effects that pertain only to the prespecified genomic or genetic patient subset.

We herein review a randomized, double-blind, parallel group, multicenter, concentration response design trial that compared the safety and efficacy of target trough plasma VPA concentrations in patients with complex partial seizures treated with divalproex sodium as monotherapy.

Researchers should also adopt a comparative effectiveness approach and design trials that allow real-world evaluation of acupuncture and related therapies.

Although double blinding (blinding investigators, participants, and outcome assessors) indicates a strong design, trials that are not double blinded should not automatically be deemed inferior.

She had to do some convincing of other people at Merck, tell them: 'Yes, this may be a bit different from the way other people are talking about HPV and its natural history, but it allows us to design trials that are possible and feasible.

Open design trials that met the general eligibility criteria were included in the sensitivity analysis.

We should develop reliable bedside assessments of the probable functional significance of a pleural effusion and design trials that provide answers that guide our management.

At the same time, we challenge clinicians and clinical trialists to interact with their colleagues in the laboratory and to design trials that will help answer questions that arise from laboratory-based hypotheses.

While the method applied to the PURSUIT data is by no means generalizable to all nonparallel design trials that are, or will be, potentially eligible for inclusion in NMA, our wish is that the provided illustration can stimulate awareness and spawn developments of other solutions that are unique to other nonparallel design trials for other NMAs.

Mathematical models can be used to elucidate these contrasting outcomes, predict the conditions under which serotype replacement is likely, interpret the results of conjugate vaccine trials, design trials that will better detect serotype replacement (if it occurs), and suggest factors to consider in choosing the serotype composition of vaccines.

This study reflects the philosophy that the only practicable way to achieve comparisons which are sufficiently large to minimise the risk of being seriously misled by the play of chance is to design trials that are extremely simple and flexible [ 62].