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Corter et al. (2009, p. 10) state, "The staff team pathways are the critical, and interwoven design strands we need to focus on at the very beginning of implementation".
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To merge data sets from three different laboratories that had used different SNP calling methods, we developed a Python script to facilitate detection, reorientation and merging of the data such that all SNPs are called relative to the design strand (the script is available upon request to J. Blanca).
Using a custom designed strand specific whole genome microarray, a total of 797 NATs targeted against annotated loci have been detected.
To identify in vivo prevalence of antisense transcripts in P. vivax clinical isolates, we performed whole genome expression profiling using a custom designed strand-specific microarray that contains probes for both sense and antisense strands.
Since the strand invasion sites can be controlled through selection of the homopurine sequence there is great flexibility for designing strand invasion motifs unique to a particular PCR amplicon, thus providing a huge potential for differentiating and detecting multiplex PCR products.
This allowed the design of strand-specific array elements that can discriminate transcriptional directions and that minimize the interference of complementary strands during hybridization.
He designed short strands of DNA to represent towns and roads such that the road strands stuck the town strands together, forming sequences of towns that represented routes (such as the actual solution, which happened to be "1234567").
Designing oligonucleotide strands that selectively hybridize to reduce undesired reactions is a critical step for successful DNA computing.
Study Design: Single-strand conformation analysis and direct sequencing of deoxyribonucleic acid were used to screen for PTEN mutations.
But whereas others mixed in one enzyme after another to cut up the lengths representing the wrong answers, Sakamoto and colleagues designed their strands so that the wrong answers spontaneously folded over and stuck to themselves to form molecular "hairpins".
In design, single-strand DNA labeled with methylene blue (MB) was used as signal probe, and auxiliary probe was designed to hybridize with two different regions of signal probe.
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