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Indeed, the Nelsons received the design designation 'O3', marking them as next in the design sequence, although they used the guns intended for the G3 battlecruisers for cost reasons and to comply with the Treaty's 16-inch limitation on main armament.
"Actually, it was a relatively simple design sequence," said Unjoo Byars, executive producer at Prologue.
Fig. 4 Design sequence using digital and physical models.
The model uses a design sequence based on either direct use of code provisions or use of safe load tables.
The use of an "economic decision" model found that such a design sequence is "cost-effective" when compared to using the design codes rules directly.
ADME-Tox properties are very important in pharmaceutical research, determining the fate of many molecules in the drug design sequence.
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The utility of PRISE was demonstrated by using it to design sequence-selective PCR primers for an rRNA gene from the fungus Pochonia chlamydosporia.
Among them, a fragment of 528 bp specific to strain Ach 1-1 (generated with the OPR-13 RAPD primer) and another one of 431 bp specific to strain 1113-5 (amplified with the OPQ-03 RAPD primer) were selected, cloned, sequenced, and used to design sequence-characterized amplified region (SCAR) primers.
These partial sequences were used as a template to design sequence-specific primers using the software, Primer3 0.4.0 [49] (Source code available at http://fokker.wi.mit.edu/primer3/; Table 1).
Prior to design, sequences were screened for possible indels in A and T homopolymer runs.
These high-AT regions not only present a problem for genome sequencing and DNA sequence alignment but also make it difficult to design sequence-specific probes with reliable hybridization dynamics.
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