Sentence examples for design of variants from inspiring English sources

This prompted the design of variants of BChE which exhibit significantly improved catalytic activity against -cocaine.

Further molecular characterization of the structure and maturation of these proteins is in progress, aimed at providing information for rational design of variants with desired fluorescence properties.

Structure function correlations described in this work will aid in the design of variants with improved activity and altered selectivity for potential industrial applications.

To aid in the design of variants with improved levels of specificity and affinity for Cl−, we solved apo and I−-bound crystal structures of YFP-H148Q to 2.1 Å resolution.

The increased understanding of hASNase3 function resulting from these studies reveals the key regions that govern cleavage and the asparaginase reaction, which may inform the design of variants that attain a low KM for asparagine.

The design of variants of the swept-frequency two-pulse phase modulation sequence for heteronuclear dipolar decoupling in solid-state NMR is reported, their performance evaluated, and compared with other established sequences like TPPM and SPINAL.

The design guidelines for the design of multi-scale fins provided after optimizations, can be useful in the design of variant cooling devices in practical engineering applications.

In contrast to random methods (error-prone PCR or DNA shuffling), site-directed mutagenesis enables the rational design of variant libraries and provides control over the nature and frequency of the encoded mutations.

These include indication for testing, array design, interpretation of variants and how to deal with variants of unknown significance and incidental findings.

For future designs of variant sets it will be important to ensure that each substitution is adequately represented in the training data set.

This knowledge will enable the design of complementary variants to rescue disease-linked mutants.