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These results support design of trials combining carfilzomib with chloroquine to improve MM therapy.
This results have guiding meaning in design of trials related to stress induced depression.
A more rigorous design of trials should be carried out in future studies.
A detailed characterization of specific EPO effects could facilitate the design of trials.
The design of trials with continuous-time survival endpoints has been studied for years, but very little is known about the design of trials with discrete-time survival endpoints.
These factors may need to be considered in the design of trials to prevent type 1 diabetes.
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The design of trial WV15799 is weak.
We compared the characteristics and designs of trials published before and included in the Picard review (old trials) with those published after the Picard review (new trials).
We also checked whether subsequently published trials cited the Picard review, and whether the designs of trials that cited the review differed from those that did not.
Therefore, greater flexibility is needed in the design of surgical trials than in the design of pharmaceutic trials.
Genomic advances not only continually influence the design of new trials, but also affect the (re design of ongoing trials.
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