Exact(3)
This approach provides an experimental basis for the design of pathogen specific, T-cell epitope-based vaccines that are targeted to majority of the genetic variants of the pathogen, and are effective for a broad range of differences in human leukocyte antigens among the global human population.
Many different methods have been developed to guide the design of pathogen diagnostic assays.
As a result, the design of pathogen diagnostic assays entails the computationally expensive comparison of target genomes with all known non-target sequences.
Similar(57)
Our results indicate that the selection of appropriate target sequence is crucial for transgenic plant against virus and provide useful guideline for the design of pathogen-derived amiRNAs.
In the long term, these efforts will form a basis for the rational design of pathogen- or class-specific immunotherapeutics, as well as adjuvants that will enhance the future development of vaccines against potential bioweapons.
We believe our studies open wide opportunities for rational design of novel, pathogen-specific and therefore more potent and efficient anti-trypanosomal drugs.
Here we describe hybseek, a Web interface for efficient design of both pathogen-specific and compatible primer pairs for DNA-based diagnostic multi-analyte assays.
Taken together, these data indicate that treatment with substrate-based inhibitors of 24-SMT, a catalyst not found in humans, can disrupt ergosterol homeostasis involved with fungal growth and therefore these compounds can provide leads for rational drug design of opportunistic pathogens.
In future, such knowledge combined with the precision and malleability of molecular techniques will allow design of multiple pathogens with different strategies and host ranges to be used for different ecosystems, and that will avoid the possibility of the host developing resistance.
This information should be an important contribution to our basic understanding of the chemistry of this glycothiol and critical in the design of novel inhibitors of pathogen enzymes that require it.
A proper knowledge of these properties may permit the design of proper anti-pathogen drugs.
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