Sentence examples for design of mutation from inspiring English sources

A better understanding of these mutational mechanisms is vital for improving the design of mutation detection strategies.

The design of mutation operators for AO programs must take these factors into account.

VM was involved in design of mutation analysis by EMMA and Sanger sequencing, data analysis and interpretation.

The identification of this MSH2 founder mutation has important implications for the design of mutation-detection strategies for the southern Chinese population.

We tackled this task by rational design of mutations at cysteine and methionine LC/A1 sites.

This approach can guide the design of mutations on the surfaces of proteins, provide geometrical details of a possible interaction, and help to annotate protein surfaces in structural proteomics.

Secondly, studies of the sequence determinants of protein aggregation culminated in the development of computer algorithms that predict aggregation-prone sequences with good accuracy, allowing the design of mutations that reduce aggregation.

Indeed, the design of mutation-specific silencing molecules is technically, and economically, particularly challenging, considering that: (i) retinitis pigmentosa is widely thought to be the most genetically heterogeneous disorder in man (Wright et al, 2010); and (ii) over 150 dominant mutations in rhodopsin are known to date (OMIN database 180380).

A crystal structure of Parkin Δ86 130 at 2.54 Å resolution allowed the design of mutations that specifically release the Ubl domain from RING1.

Regardless of its limits, in silico design of mutations increasing affinity between ligand and its receptor can be a useful tool because ligand-receptor interactions do not evolve for the maximal affinity but for affinity optimal to enable proper signalization.

The crystal structure of the Pikp-HMA/AVR-PikD complex enabled design of mutations to alter protein interaction in yeast and in vitro, and perturb effector-mediated response both in a rice cultivar containing Pikp and upon expression of AVR-PikD and Pikp in the model plant Nicotiana benthamiana.