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Previous attempts to improve the power output of microbial fuel cells have primarily focused on overcoming electrochemical limitations, but a better understanding of how microorganisms transfer electrons to electrodes could lead to the design of microorganisms with improved electron-transfer capabilities [1] [4].
One of the aims of synthetic biology is the rational design of microorganisms for biotechnological applications.
This approach has been used for many years in the design of microorganisms for the production of many valuable metabolites and commodity chemicals and, more recently, biofuels (Atsumi et al. 2008a, b; Atsumi and Liao 2008; Kim et al. 2007; Lee et al. 2009; Withers et al. 2007; Yan and Liao 2009; Zhang et al. 2008).
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Herein, fermentation procedures for the formation of biofuels like ethanol or butanol will be covered, together with insights on emerging trends like metabolic engineering, and the design of tailored microorganisms for the formation of an array of different chemicals.
Systems biology helped to facilitate the rapid biocatalyst discovery and detailed mechanism analysis, which could in turn guide the reverse design of engineered microorganisms and bioprocesses for cost-effective and efficient biomass conversion.
Increasingly in recent years, however, metabolic engineers have drawn inspiration from natural systems and have begun to harness dynamically controlled regulatory machinery to improve design of engineered microorganisms for production of specialty and commodity chemicals.
Our engineering methodology enables the flexible design of industrial microorganisms for the efficient on-demand production of chemical compounds with therapeutic applications.
These results represent a first step for the design of a microorganism capable of utilizing green macroalgal biomass for the production of biofuels and other valuable bio-products.
Recent advances in system biology and synthetic biology are allowing us to perform metabolic engineering at the whole cell level, thus enabling optimal design of a microorganism for the efficient production of drugs and drug precursors.
Emerging systems biology approaches to the study, design, and evolution of microorganisms interacting with electrodes are expected to contribute to improved microbial fuel cells.
The enzymes involved in PLA production were identified and characterized, which makes possible the rational design and construction of microorganisms suitable for PLA production with metabolic engineering.
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