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The dimers follow the prototypical design of known bacterial repressors with two helix turn helix (HTH) domains binding to successive major grooves of the DNA.
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Drug design studies of known purine compounds revealed that both positions-2 and -6 were suitable for incorporating bone-seeking moieties.
Examples of critical parameters may include primer design, location of known polymorphisms, the G+C content of the region of interest, fragment length, type of mutations to be detected and location of mutations within fragments.
They can design reserves of various sizes, with or without connecting corridors, and run simulations to assess their designs using ferrets of known genotypes from a zoo.
Initially, multiple degenerate oligonucleotide primers (DOP) and probes were designed from sequences of known plasma membrane associated syntaxins.
Degenerated primers were designed through alignment of known sequences available at GenBank.
Inspired by the discovery of the "God Particle" and set to music by Stravinsky and Cheryl Frances-Hoad, it's a work whose intricate patterning and vivid energies mimic the design of the known uniterse.
A statistical design of experiments known as central composite design (CCD) has been used to collect the data for developing the fuzzy model.
The goal was to determine the empirical effects of known design factors (inlet momentum and inlet orientation) on hydraulic performance indicators using a factorial design.
A number of designs incorporate aspheric shapes, of known p-values on the front and back surface of contact lenses.
Primers were designed on the basis of known sequence information of Nipponbare genome (TIGRv3) by using the blast tool of Gramene (www.gramene.org).org
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