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Altmann, K. H. et al. Second-generation antisense oligonucleotides: structure-activity relationships and the design of improved signal-transduction inhibitors.
Implications for the design of improved spacer meshes are discussed.
These results may be relevant to the understanding of gecko morphology and the design of improved synthetic adhesive systems.
Viral vectors that elicit CD8 T-cell responses of unprecedented breadth and promiscuity may aid the design of improved HIV vaccines.
These studies provide a structural basis for the rational design of improved Ca2+-sensitive probes.
This information will ultimately guide the design of improved human spinal instrumentation systems.
The implications for design of improved integrin antagonists will be discussed.
These can provide useful guidelines for the design of improved biocatalysts.
Thus, our results provide a valuable framework for the structure-based design of improved antiandrogens.
Altogether, our data suggest the benefit of this modification for the design of improved siRNA delivery systems.
Understanding the impact of a scaffold on attached cells will facilitate the design of improved tissue engineering materials.
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