Sentence examples for design of combinations from inspiring English sources
Though differential drug interactions are common and, we propose, important in the design of combinations, they were observed against an overall strong conservation of drug interactions between two species separated by hundreds of millions of years of evolution24.
Further understanding of the molecular biology of wound repair and regeneration will likely result in the design of combinations of scaffolds and soluble natural factors or synthetic small molecules that confer regenerative capacity on regeneration-deficient tissues.
This approach defines mechanisms of drug resistance, allowing rational design of combination therapies for cancer.
However, the rational design of combination therapy represents a potential prerequisite for its effectiveness.
Our results will help to advance the design of combination strategies to enhance the efficacy of imaging-guided cancer therapy.
As more targeted therapies become available, mathematical modeling will provide an essential tool to inform the design of combination therapies that minimize the evolution of resistance.
We also explore additional clinical applications for PD biomarkers: molecular response based dosage regimen optimization, design of combination therapies, and development of companion diagnostic biomarkers.
The impact of drug sequence and ratio on the interactions argues for incorporation of these parameters into the design of combination chemotherapy regimens.
Another opportunity for improved design of combination therapies is through quantitative systems pharmacology approaches integrating cell signaling network models with pharmacokinetic-pharmacodynamic (PK/PD) models [83].
Together, these studies have implications for the design of combination therapies that target alternative pathways and appropriately adapted to particular characteristics of the tumor progression.
