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This biomechanical discrepancy is a hurdle in the design of bone replacements.
Design of bone substitute biomaterials requires an understanding of how bone behaves mechanically at different scales.
The design of bone substitutes involves the creation of a microenvironment supporting molecular cross-talk between cells and scaffolds during tissue formation and remodelling.
One of the critical issues in orthopaedic regenerative medicine is the design of bone scaffolds and implants that replicate the biomechanical properties of the host bones.
This chapter aims to provide a fundamental understanding of use of multiscale modeling approaches for design of bone tissue engineering scaffolds with predictive mechanical properties.
These findings might have important implications for our understanding of the fundamental MSC functions and the optimal design of bone regeneration materials.
Similar(48)
These findings provide useful information on the design of bone-seeking therapeutic radiopharmaceuticals.
The design of bone-targeted pyrido[2,3-d]pyrimidin-7-ones as Src tyrosine kinase inhibitors is described.
For the present time, this study confirms proof of concept that the mechanism designed for the purpose of bone segment transport within an intramedullary nail works.
The design of synthetic bone grafts to foster bone formation is a challenge in regenerative medicine.
Important geometric design measures of bone substitute include pore size, interconnection size, porosity, permeability and surface area of the substitute.
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CEO of Professional Science Editing for Scientists @ prosciediting.com