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This strategy was exploited in the design of a compound to treat malignant gliomas [107].
The microcapillary lens, formed by air bubbles in a hollow core glass capillary filled with epoxy, is a novel design of a compound refractive lens for X-rays.
Finite element analysis was used to guide the design of a compound cantilever to allow measurement of forces in any direction in the plane of the sensor.
The design of a compound control is presented for the servo system of hydraulic flight motion simulator, which suffers from highly nonlinear dynamics, large parameter time-variation and severe load coupling among channels.
The design of a compound with the correct geometries to maintain all of the bound interactions is a large challenge.
The best example to date of the rational design of a compound to block cytoadherence comes from Dormeyer and co-workers (Ref. 180), who used the crystal structure of ICAM1 to identify a compound to block parasite binding to ICAM1 in vitro.
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This paper describes a new approach for using 3D-printers where the students shall collaborate on a design of a compounded product, consisting of different parts.
We applied this approach for the design of a small compound library for the interaction with α4β2∗ nicotinic acetylcholine receptors (nAChRs).
Here we report the design of a peptidergic compound, Ac-DGGLAG-NH2, called P21, when administered peripherally, enhanced learning as well as both short-term and spatial reference memories of normal adult C57Bl6 mice.
Design of a Multiple Compound Parabolic Concentrator, or MCPC, was performed by taking into account both that photocatalytic degradation efficiency is a function of the square root of photon flow intensity that excites the photocatalyst and that TiO2 is able to absorb more sunlight (photons) than the provided in utilising a 1-sun geometric concentration ratio (CR).
We have previously reported the design of a lead compound 1a for the joint inhibition of neprilysin (NEP, EC 3.4.24.11), angiotensin converting enzyme (ACE, EC 3.4.15.1) and endothelin converting enzyme (ECE-1, EC 3.4.24.71), three metallopeptidases which are implicated in the regulation of fluid homeostasis and vascular tone.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com