Sentence examples for design mutations from inspiring English sources

The putative model can be used to design mutations that change the substrate specificity.

Here, we tested the ability of PAPA to design mutations to turn non-prion proteins into prions.

In this study, two computational tools were used to predict T-cell epitopes within Hirudin variant III (HVIII) sequence, and design mutations that would lessen its antigenicity.

The combination of these simple physicochemical properties with a previously described calculation of β-strand contiguity allowed us to design mutations that changed the fibrillogenic propensity of α-synuclein in predictable ways.

Study Design: Mutations were studied in the following 5 groups: 47 consecutive women with preeclampsia, 49 women with preeclampsia and with hyperhomocysteinemia, 36 women with preeclampsia but without hyperhomocysteinemia, 127 women with familial preeclampsia (typed for C677T mutations only), and 120 control subjects.

This structure enabled the authors to design mutations in STIL to dissect the function of the STIL PB3 interaction, revealing that it is essential to promote centriole overduplication.

JK, XY, AS, PZ, MA, MN, UB, SG, SG, YD, LY, AM, VV, SR and BT participated in the study design, mutation detection, pathological evaluation, and sample collection.

However, in the present design, mutation carriers are already selected on the basis of disease status (where affected individuals are over-sampled).

Combining computationally and rationally designed mutations produced unique designs with heterodimer purities greater than 90%.

This combinatorial approach does not require preconceived notions for designing mutations.

The thermostability of mesophilic xylanases has been increased considerably by designed mutations.