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We discuss the role of early phase clinical trials, defined as phase I and non-randomised phase II trials, within the clinical context and current therapeutic landscape of P-B tumors and postulate how translational studies and trial design may enable better realization of emerging targets together with a proposed model for future patient management.
That the population studied has many underlying diseases affecting all organ systems suggests that the electronic patient record design may enable application to many fields of medical practice.
On the positive side, this cross-sectional design may enable relationships to be identified that arise from effects of 'events' on physiological variables: such relations may also be important, and may be missed in prospective studies that censor follow-up at the occurrence of an event.
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The recognition of the importance of temporal information processing as a design constraint may enable us to better understand the underlying design principles of biomolecular networks.
A novel electrodeposition technique for preparing the catalyst layer in polymer electrolyte membrane fuel cells has been designed, which may enable an increase in the level of platinum utilisation currently achieved in these systems.
Aiming predominantly at monitoring of decision solutions and their quantitative and qualitative consequences, the designed tool may enable more awareness of controllers within the decision processes, though not intending to replace them.
This suggests a new material design strategy that may enable the use of the a-Si for Na-ion battery anode applications.
My research highlights the ways in which the design of websites may enable users to become more active agents in political campaigns and in the election process.
The use of more sensitive and sophisticated designs and analyses may enable more accurate characterization of longitudinal headache epidemiology and determine with greater certainty the efficacy of treatment.
Future studies of the receptor‐bound structure of insulin may enable design of novel agonists for the treatment of diabetes mellitus.
Better understanding of the mechanisms of He interactions with interfaces may enable design of interfaces that control He while remaining mechanically sound.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com