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In fact, there is no formal method to set safety requirements in the early design from knowledge abstraction.
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The input space is designed from knowledge of those variables that affect the behaviour of the output parameter.
Further, the information-processing paradigm is a general theory and rather robust to changes in circumstances, and it will allow us to say something about what might be designs from knowledge about what is.
This class of peptide is short and can be readily molecular-designed from knowledge gained in the literature, we designed and produced the functionalized self-assembling peptides.
Complex cis-regulatory sequences like the ones driving expression of the Drosophila even-skipped gene have proven difficult to design from existing knowledge, presumably due to the large number of protein protein interactions needed to drive the correct expression patterns of genes in multicellular organisms.
A CYP-focused biologically relevant fragment library ("CYP biofragment library") was designed starting from knowledge of CYP ligands found in the protein data bank (PDB [ 15] Figure 1).
In our studies, constraints were designed from our knowledge of the family classifications of the sequences resulting in four constraints.
The paper set out to provide a framework of mechanism design of synergies gained from knowledge alliance made up of library consortium and R&D institutions.
The goal of the studio is to pioneer a new design approach that arises from knowledge and experience of multiple disciplines and to deepen our newly established collaborations with academic and industry partners.
Pharma, must move from the design of extracting value from knowledge stocks, to extracting value from "knowledge flows", per John Hagel.
Drug design efforts benefit greatly from knowledge of the 3D structures of protein-ligand complexes.
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