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But the halting of its secret enrichment and weapon design efforts in 2003 proves only that Iran made a tactical move.
American officials said that Iran halted warhead design efforts in 2003, a conclusion they reached after penetrating Iran's computer networks and gaining access to internal government communications.
The availability of substantial quantities of active, homogeneous enzyme will be of great help in future structure-based drug design efforts in the search for efficient protease inhibitor drugs to treat AD.
This situation may change as recent publications have disclosed valuable structural information for TLR1/2, TLR2/6, TLR3, MyD88, and IRAK-4, which may help stimulate additional structure-based drug design efforts in these areas.
Drug design efforts in the emerging 2-aminothiazole-4-carboxamide class of CHK1 inhibitors have uncovered specific combinations of key substructures within the molecule; resulting in significant improvements in cell-based activity while retaining a greater than one hundred-fold selectivity against CDK2.
(Alas, while the video above suggests they threw some pretty serious design efforts in here, the tattoo ends up looking a bit like a mole you'd want to have someone check).
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This information can then be used to drive the quality of model input data and focuses design effort in the most important directions.
A peak-current-controlled buck converter can give reasonable LED current variation over a wide range of input and LED voltages and needs no design effort in feedback control design.
In 2011, Felder led various independent design efforts resulting in multiple design awards, including runner-up in the Metropolis Magazine Next Generation Design Competition an entry which recently garnered Boston Society of Architects recognition.
The design efforts resulted in a detailed, published study protocol, confirmed and approved by the regulatory authorities [ 11].
Their structure-based design efforts eventually resulted in several novel AIs with IC50 activity in the range of 21.7 μM to 9.4 nM.
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