This may reflect differences in study design, difficulty in controlling for confounders (such as ethnicity, age, disease duration, concomitant therapy, and smoking), or simply the inadequacy of proposed markers [ 47- 49].
Presently in China many challenges are existing in building energy efficiency, such as the detachment between building design and its energy efficiency, the complicated working process on building efficiency design, the difficulty for architects to get efficient facilities, all of which cause problems to the design of building energy efficiency.
However, it greatly increases the design difficulty.
Aside from the design difficulties in producing bras for fuller-chested women, Zak suggested other reasons that some brands may not want to produce larger sizes.
To test our hypothesis, we sampled responses using a random sampling approach and examined student responses for experimental design difficulties.
Sasuke's design caused difficulties for Kishimoto as he drew the manga scenes, but he has grown to enjoy drawing him.
The difficulty for design teams and the requirements community is arriving at a good estimate of what a particular configuration may look like, as well as what technologies are needed to enable it, given a set of strict requirements.
A large gap of rheological properties between the raw and pretreated lignocellulose raised a difficulty for designing proper pretreatment reactors with maximum efficiency and minimum power consumption.
Another difficulty for designing predictable behaviour in interconnected modules is the fact that different connected modules might have varying sensitivity to the intra- and intercellular environment.
The complexity of hardware design methodologies represents a significant difficulty for non-hardware focused scientists working on accelerating the simulation of complex bio-inspired applications.
