Exact(1)
The crystal structure of a monobody generated from the new library in complex with its target, the Abl SH2 domain, revealed that a concave surface of the monobody, as intended in our design, bound to a convex surface of the target with the interface area being among the largest of published structures of monobody target complexes.
Similar(56)
In addition, when immobilized to agarose beads, all three α-sheet designs bound species from the toxic TTR and Aβ preparations preferentially over the nontoxic fresh samples.
10.7554/eLife.01681.009 Figure 3. Immobilized designs bind toxic soluble oligomer from solution.
If your design isn't fun, then your design is bound to fail in the long run.
Wire chandeliers, copied from an 18th-century Italian design, are bound in sackcloth.
It is one of 7 former palaces of identical rococo design that bound the Place Stanislas, which is considered one of the most beautiful squares in the world.
Clean energy technologies that are not inclusive of the community in their application and design "are bound to fail," says Diaz. "Too many are based on prioritising the producer and manufacturer, not the beneficiary.
Clerical designs are bound to tradition and slow to change.
In that context, Snapchat feels liberating, while Instagram Direct, though beautifully designed and bound to succeed, feels like another product of the Facebook empire, built to capture even the moments you thought you wanted to keep private.
An aptamer was designed and bound to thrombin by changing its conformation.
Of the remaining four designs, three bound to the PAK1 with affinities tighter than 350 μM.
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