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Multicenter, prospective mega trials with a randomized and controlled design are needed to resolve these issues.
Further studies with a longitudinal design are needed to confirm these findings.
To check the performance of a manufacturing system, formal methods of design are needed.
However, improvements in vaccine design are needed for efficient cancer immunotherapy.
Further investigation into pathophysiologic targets and novel approaches to clinical trial design are needed.
Improvements in phase 2 trial design are needed to reduce these false-positive signals.
Larger studies with a prospective design are needed to confirm these findings.
In all these areas modifications in the current ITER design are needed to accommodate the TMB testing.
To design accessible technology accepted by the target group, comprehensive methods of user-centred design are needed.
Future studies employing a longitudinal design are needed to better understand the direction of the observed associations.
For underground structures, the prediction of structural service life and methodology for durability design are needed to estimate structural durability.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com