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WR authored the study design, applied for the funding and revised the paper critically.
JG, HM and DM conceived of the design, applied for funding, obtained ethics approval, organized the meeting, interpreted the findings and wrote and edited the manuscript.
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At the same time, she said, she was riffing on an old term for design: "applied art".
The 3 by 3 factorial design was applied for this purpose and the approach for calculating sample size was proposed.
Plackett Burman design was applied for pre-evaluation and 23 central composite designs with star points for parameter optimization.
Screening experimental design was applied for investigating knowledge space.
A preliminary Plackett Burman design was applied for screening.
A three-level Box-Behnken design was applied for optimization.
Box-Behnken experimental design was applied for optimization of nanoethosomes.
A 32 full factorial design was applied for optimization procedure.
A similar experimental design was applied for two successive years.
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