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C-Galactosides have been used as scaffolds to design a library of non-hydrolysable inhibitors of cholera toxin (CT).
For the construction we used the interpolatory discrete splines which enabled us to design a library of perfect reconstruction filter banks.
The functionality maps are also used to design a library of disubstituted indoles that might prevent the binding of the protein substrates.
The union of genomic editing machinery, DNA inkjet printers, and bioinformatics algorithms allows engineers to design a library of thousands of unique oligos as well as build and test these designs on a ∼2 months time-scale and at a cost of roughly ∼0.3 cents per base pair.
A rough classification in the proposed classes thus seems not sufficient as a means to rationally design a library of promoters covering a wide range of promoter strengths.
Thus, the context of the present study is to establish a generic lipid-modification method that could apply to various active therapeutic peptides in order to design a library of peptide-based nanomedicines.
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Protein evolution relies on designing a library of sequences that capture meaningful functional diversity in a limited number of protein variants.
To test this hypothesis, we designed a library of artificial amphiphilic peptides based on the sequence (FEFEFKFK 2 by substituting combinations of the non-polar residues glycine, alanine, valine, leucine and isoleucine for phenylalanine.
This setback served as an impetus for rationally designing a library of next-generation antibiotics that exhibit a bactericidal effect on resistant P. acnes and exert an immunomodulatory function to reduce inflammation.
In this study, we designed a library of compounds based on the structures of well-known ligands of the 18 kDa translocator protein (TSPO), one of the putative components of the mPTP.
In order to discover novel probes that may help in the investigation and the control of bacterial biofilms, we have designed a library of triazole-based analogs of 2-aminoimidazole marine alkaloids: naamine A and isonaamine A. Twenty-two compounds were screened for their biofilm inhibitory activity against two strains of Gram-negative bacteria.
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