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Full description of trial methodology is given in the paper reporting main trial findings [17].
A poor description of trial design in research papers complicates the selection of manuscripts that are eligible for inclusion when conducting a study on publication bias.
The trial finding an effect was at unclear risk of both selection and detection bias due to an inadequate description of trial methods (Inyang Etoh 2009 NGA).
377 396 397 398 399 400 This detailed report provides the most comprehensive description of trial methods (including the full protocol) and all published and unpublished analyses.
This detailed description of trial methodology can serve as a template for the development of future treatment scheme for active TB patient with DM.
In the third trial (Inyang Etoh 2009 NGA), at unclear risk of bias due to inadequate description of trial methods, artesunate performed similarly to praziquantel with 28% treatment failures at two months (Analysis 12.1).
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A simple description of trial-by-trial learning of cue-target contingencies is provided by reinforcement learning models such as Rescorla Wagner (Rescorla and Wagner 1972).
Where possible, a comprehensive description of trials interventions has been presented for the majority of trials (additional file 2).
CONSORT can also be used by peer reviewers and editors to identify reports with inadequate description of trials and those with potentially biased results, [ 1, 2].
As they read through the records, the researchers discovered the importance of documents called clinical study reports, which are thousands of pages long and contain details as varied as descriptions of trial protocol and design and the ingredients of the placebo pills.
Most of the trials provided limited descriptions of trial design and the sample size calculation, which precluded estimating the statistical powers; and randomizations were only mentioned without further details, which precluded a proper evaluation of how the trials were conducted.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com