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Instead of a finite number of sequences, such calculations result in a probabilistic description of the sequence ensemble.
The main extensions are the consideration of PSK signaling, the consideration of the spectral efficiency with different out-of-band power thresholds, the extended description of the sequence optimization strategy including the explanation of the lower bound on the achievable rate and the overall performance comparison for a large number of transmit signaling schemes under the same conditions.
Extensive spectroscopic studies have provided a description of the sequence of intermediates generated during the photocycle (Fig. 1) [8], [8], while functional analysis of a large number of mutants [9] [11] had identified key residues that line the path of the proton at different stages of transport.
Moreover, a structure-based predictive understanding of peptide:MHC binding provides a physical explanation for the nature of the binding interactions, while purely peptide sequence based learning methods merely provide a description of the sequence characteristics of preferred MHC-binding ligands.
A full description of the sequence extraction procedure is available in the online supplement.
Thirty sequences were applied in two modalities to each ear: a verbal description of the sequence (naming) and humming.
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The description of the sequences in [4, 5] requires some work, so we do not go into the details.
Simulated metagenomic DNA samples were then subjected to high-throughput sequencing using Sanger sequencing and pyrosequencing technologies (see Methods for a description of the sequencing protocols).
A total of 46 AL sequences from Mayo, 48 AL sequences from Comenzo, and 47 AL sequences from Prokaeva were used for this study (for a detailed description of the sequences used, see the Methods section).
A more detailed description of the sequence-processing workflow can be found in Text S1.
2. There is no description of the sequencing methods.
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