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The database entry for that study includes a short description of the screen phenotype: Elevated Rad52 foci, a summary of the manuscript describing the screen: Alvaro et al. 2007.
In response to specific reviewer concerns about the description of the screen (below), we have removed the proof-of-principle details of the screen from Figure 2 (to a child figure and legend for those that would like to see this part of the screen) and have streamlined the text accordingly.
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While two of them did not finish the experiment, data of three participants were excluded because for them there was at least one of the experimental conditions in which no regular trial was left after screening (see Data Analysis for a description of the screening procedure).
This should encompass a detailed description of the screening intervention under evaluation and its comparator.
A description of the screening process, participation rates, and reasons for accepting or declining screening has been previously reported [ 54].
We provided women with a description of the screening test prior to asking items about the exam.
However, this study provides a rich and detailed description of the screening process from the perspectives of those who implement it, which strengthens the findings.
Unfortunately, I found the description of the screening, especially all the computations, statistical calls, and subsequent validations, to be so sloppily described that it is difficult to understand what was actually done.
The expert panel recognizes these disparities and their rationale, and recommends the implementation of a standardized and common nomenclature for an objective and scientifically sound description of the screening test panel being offered and the reporting of results.
A full description of the screening pilot can be found in the evaluation reports for each round. 1 3–5 The primary care trusts (PCTs) taking part in all three rounds were Coventry, Rugby and North Warwickshire.
For a description of the screening strategy, a typical HPLC mass spectrometer trace of the final method, the corresponding analytic identification parameters, and compound structures with Biochemical Nomenclature, see Supplemental Figure 2, Supplemental Figure 3, Supplemental Table 1, and Supplemental Table 2, respectively.
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