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A detailed description of the modified PAED scale is presented in Additional file 1: Table S1.
For this purpose, firstly, a detailed description of the modified Holmberg Persson approach was made.
A detailed description of the modified protocol can be found in the Supplementary material.
In the remaining 94 trials no exclusions were reported, despite the description of the modified intention to treat approach.
40 We were unable to investigate any possible discrepancy between the description of the modified intention to treat in the protocol and the one reported in the respective published trial.
Statistical analyses did not indicate any positive association between the number of conditions provided in the description of the modified intention to treat and the proportion of participants excluded from the analysis (P=0.11).
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6 24 All of these reasons were mentioned in the descriptions of the modified intention to treat reported in our survey.
Inconsistent and multiple descriptions of the modified intention to treat approach may cause failure to achieve the standard intention to treat principle, which is the best method that preserves randomisation.
22 Indeed, in our cohort of trials different terms were used, such as post baseline assessment, missing outcome, lost to follow-up, or "last observation carried forward," which imply the reporting of missing data under the description of a modified intention to treat approach.
Consecutively, the modeling concept of TILAR will be outlined, followed by the introduction of ExTILAR and a detailed description of its modified modeling concept.
Each student group was given a written description of the simulated emergency (modified after Whitfield 9): 'You are called to help a person who has collapsed.
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CEO of Professional Science Editing for Scientists @ prosciediting.com