Unlike the earlier description of regulation of DNA transcription as a biological switch which simply turns on and off, scientists now understand that DNA transcription is a much more complex process.
Using a mathematical description of regulation of gene expression (Equation 1) and a procedure for computation of its parameters from experimental data, it was possible to construct a complete numerical model of the genetic network of yeast cyclins active during cell cycle.
This diagram was constructed according to the description of regulation of muscle mass [ 31, 32].
The initial materials gathered opened other pathways to obtain additional data, such as references to articles, names of companies, and individual and collective social actors involved in the situation, and description of regulations, among others.
For instance, RA is a potent regulator of RAR-β expression in different cell types, both of neural and non-neural origin [6], [23], [24], [25], although there are also descriptions of regulation of RAR-α by estrogen [26], RAR-β and RXR-β by interleukin-1 [27], RAR-β by nerve growth factor [28], as well as RAR-α and -γ by β-carotene [29].
Alternatively, taken as a model of gene regulation, Eq. (1) is a generic phenomenological model of protein concentration dynamics, not a mechanistic description of gene regulation.
However, to the best of our knowledge, this is the first description of coordinate regulation of the expression of the genes in this family, which indicates the participation of common mechanisms of transcriptional regulation: shared control regions or the same control elements in each gene.
These cards should be used according to the scientific description of physiological regulation of human immunological defense.
These varied experimental datasets augment computational TFBS prediction methods, and aid in the description of transcriptional regulation on the scales of single genes to the entire genome.
It is the most distinguishing and valuable feature of our game design that the cards should be used according to the scientific description of physiological regulation of human immunological defense.
When coordinated, the result may be the description of genetic regulation mechanisms at a level of detail that would allow the confident prediction of cell behavior under previously untested circumstances.
