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The majority of the studies published since the initial report describing TRAIL have focused on the in vitro and in vivo tumoricidal activity of TRAIL.
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It is noteworthy that the model by Laussmann et al.[ 33], describing TRAIL-induced activation of caspase-8, emerged from the original study by Bentele et al.[ 18].
Mr. Elkan described trails created by herds of forest elephants as "boulevards".
Jungers and Stern (Jungers and Stern, 1981) also described trailing elbow flexion in gibbon brachiation, although without indicating whether this was associated with a loop transition.
When combining our result with the fact that Flavopiridol and Roscovitine also inhibit CDK9, it appears reasonable to assume that their previously described TRAIL-sensitizing capacity is likely owed to their CDK9-inhibitory capacity.
For reasons of innocent ignorance or greed, Mr. Halpin said, towns in the Lone Star State have long tried to capitalize on the mystique that the trail has attained, even though he and his group's members say they believe that it is inappropriate to use the Chisholm name in describing the trails.
Taken together, we describe that TRAIL activates NF- κB by the DDs of TRAIL-R1 and TRAIL-R2.
To our knowledge, two drugs, idarubicin and mitoxantrone, have not been previously described as TRAIL sensitizers for any cancer cell type and are therefore new candidates that can be used in combination with TRAIL.
It describes each trail's length and surfaces; some are wheelchair-accessible.
Two unique properties have been described for TRAIL that renders this cytokine highly attractive for cancer therapy.
We recently described that TRAIL fails to trigger apoptosis in primary hepatocytes but enhances their sensitivity to the Fas pathway.
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CEO of Professional Science Editing for Scientists @ prosciediting.com