At the same time, some who know the suspects described marked changes in their personalities in the last year, including an apparently deepening interest in Islam.
Previous autopsy reports of INAD and ANAD have also described marked cortical involvement of LBs [ 1, 8].
Our data describe marked intertumour differences in the expression of several clinically relevant genes, and highlight novel associations with tumour histology, chemotherapy response and survival.
CYP3A4 is a minor metabolic pathway for the antipsychotic risperidone, but two studies describe marked decreases in plasma concentrations when rifampicin is co-administered [ 37, 38].
Reports of tau pathology in inherited prion diseases consistently describe marked dystrophic neurites with hyperphosphorylated tau, accentuated in the vicinity or located within amyloid plaques.
Against the backdrop of overall similar beta cell transcriptomes, we describe marked differences in the repertoire of receptors and long non-coding RNAs between mouse and human beta cells.
Post-mortem studies describe marked regional variations in the extent of cholinergic losses with the temporal lobe displaying the most significant losses of cholinergic fibers (Geula and Mesulam, 1996).
In summary, therefore, we describe marked individuality in the expression of clinically relevant genes in ovarian tumours, and highlight novel associations with tumour histology and survival, consistent with individuality in disease progression and treatment response.
We have described marked inter-tumour differences in GSTP1 expression but, unlike fibroblast growth factor (FGF) family genes, pre-treatment tumour GSTP1 expression was not influenced by tumour histology or associated with altered survival (Smith et al, 2012).
