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As a research scientist, albeit in biophysics rather than medicine, it seems to me that Ioannidis' claim describes scientific business as usual.
Kuhn (1962) describes scientific revolutions as occurring when existing theories are no longer perceived to be satisfactory explanations and this dissatisfaction with existing theory drives scientific thinking and research, ultimately resulting in the formation of new theories.
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He lets himself describe scientific judgments as purely that: scientific.
The great zoologist Peter Medawar famously described scientific research as "the art of the soluble".
She described scientific evidence on the effectiveness of various contraceptives in preventing unintended pregnancies.
News reports have described scientific research conducted by the Pentagon and other federal agencies on discovering the origins of nuclear materials and devices.
For better or worse, this contributed to a popularising of the concept of the "paradigm shift" – a term that had previously been restricted to describing scientific revolutions.
He even described scientific management as "the most powerful as well as the most lasting contribution America has made to Western thought since the 'Federalist Papers'".
Many philosophers and scientists find this perspective attractive and satisfying, even as they acknowledge that it fails to describe scientific theories as they really are.
The F.T.C. has said only that, when a tobacco company purchases advertising space to describe scientific findings concerning smoking and health, it must do so in a manner that is not false and misleading.
They exemplified the need for understanding and patience when describing scientific theories and religious ideologies.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com