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Codon optimization describes gene engineering approaches that use synonymous codon changes to increase protein production.
The chapter describes gene expression, cell metabolism, cofactor availability, oxygen transfer, and catalyst stability as possible targets for improving catalyst efficiency.
The present study describes gene therapy strategy against Hsp90 using a new GR-targeted liposome-amiR-Hsp90 lipoplex formulation for treating cancer.
This chapter describes gene switching, a simple but powerful method that employs antisense technology to specifically shut down an endogenous gene and replace it with an engineered construct transfected into the cells under study.
A recent publication that describes gene therapy treatment of a patient with an inherited blistering skin disease, epidermolysis bullosa, demonstrates for the first time that gene therapy can cure a disease of solid tissue.
Therefore, an important question pertains to which assumption best describes gene expression data.
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In view of the significance of these protein-DNA interactions to cellular physiology, we modified the existing InterMine Interaction class, which describes gene-gene interactions, to define a new class named ProteinDNAInteraction.
PANTHER describes genes in terms of biological processes, molecular functions, and pathways in hierarchies up to three levels.
Chapter 11 then describes gene-silencing approaches, focusing on RNA interference.
The "flat" profile describes genes that do not show transcript abundance changes (null results).
In this work we use a three state model that describes genes as induced, repressed, or non-regulated.
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