GO describes functions of genes and relationships between genes using standard terms.
Here we review a recently described function of two LTPs, OSBP and its yeast homolog Osh4p, which consists in creating a sterol gradient between membranes by vectorial transport.
Another well described function of MSCs is their ability to migrate to damaged tissues.
Since then, it was used in multiple settings describing function of foot and ankle.
The earlier described function of SGN3/GSO1 in the formation of an embryonic cuticle by contrast is fully redundant with that of its homolog GSO2.
As shown in Fig 2C,D, PP2AC-silenced cells are mildly impaired in the repair of X-ray-induced DSBs, which is consistent with the previously described function of PP2AC in the repair of camptothecin-induced lesions (Chowdhury et al, 2005).
This new described function of VP16 correlates with its large-scale chromatin remodelling features (Tumbar et al., 1999) and potent transcriptional activator functions (reviewed in detail by Kutluay & Triezenberg, 2009).
The main described function of most uORFs is to regulate translation of downstream long ORFs, either interfering with the translation of the downstream ORF, or collecting ribosomes in order to promote it.
GeneRIF is a curated set of links from Entrez Gene to MEDLINE®/PubMed® citations provided by annotators at the NLM and supplemented by validated public submissions that specifically refers to a described function of the gene [ 32].
Since further research revealed that Tbx1 is not necessary for skeletal muscle specification, differentiation, patterning or activation of the embryonic myogenic program, this is the only described function of Tbx1 in relation to embryonic muscle development [ 23].
Hence, the observed slight reduction of Smad signaling and caspase 3 activation in Caveolin-1 overexpressing cells might derive from the previously described function of caveolae with respect to TGF- β receptor degradation.
