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Michael Kurilla, director of the office of biodefense research affairs at the National Institute of Allergy and Infectious Diseases, describes a target as "some molecular entity where if its activity is impaired or enhanced you can intervene in some productive way in a part of a pathological process".
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Part of the problem is that he is trying to describe a target in motion, with roots almost as tangled as the chaos it seeks to eradicate.
Multi-modal image fusion is necessary for describing a target abundantly.
In addition, the model to describe a target consumer is provided for grounding the identified value.
Such models may be studied as mathematical objects or may be used to describe a target system (some kind of physical, biological or economic system, say).
Dialectical behavior therapy (DBT), a comprehensive, cognitive-behavioral treatment, provides structure and guidance in this area by describing a target hierarchy relevant to telephone coaching.
Of the 108 (23%) trials describing a target condition based modified intention to treat, 78 (72%) listed at least one additional type of deviation.
In this paper, we described a targeting semi-synthesis of 6-isomers of 5, 8-O-dimethoxyl ether of shikonin via an 'intra-molecular ring-closing/ring-opening' strategy, coupled with introduction of a bulky substituent for regulating distribution of electron density on naphthoquinone scaffold.
Here, we describe a targeting strategy for antitumor drug delivery by conjugating a crosslinked multilamellar liposomal vesicle (cMLV) formulation with a tumor-penetrating peptide, iRGD.
We describe a targeting vector and protocols that achieve this at high frequency and with very few false positives in Drosophila, either with a two-generation crossing scheme or by direct injection in embryos.
Here, we describe a targeted gene knockout system for C. cellulolyticum based on a mobile group II intron originating from the Lactococcus lactis L1.LtrB intron, which has been successfully used in several clostridial species to disrupt genes [ 15- 17].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com