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In each of these circumstances, radiotherapy was not affected unless the described toxicity worsened after discontinuing capecitabine.
It was now investigated whether altering steady-state subcellular localization might suppress the previously described toxicity of GAL-expressed Def11-500.
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The property changes can lead to e.g. differences in cell penetration, in the mode of action and in the toxicity level, and may also vary in dose-response relationships describing toxicity.
Table 1 describes toxicity incidence and Table 2 describes the incidence of the most common individual toxicities by grade.
GELA LNH 93-1 [ 31] and 93-4 [ 35] did not describe toxicity individually for each arm, but life-threatening toxicity appeared to occur in a small number of patients.
The National Cancer Institute Common Toxicity Criteria, version 3.0, were used to assess chemotherapy-related toxicity and the Radiation Therapy Oncology Group (RTOG) acute and chronic toxicity criteria were used to describe toxicity due to RT [ 13].
Thirty years ago numerous papers pointed out that different dose response models could describe toxicity data about equally well in the high-dose range, but they could differ by orders of magnitude at low doses (see NRC 1983).
There are no available reports describing toxicity of extracellular laccase, the crude extract of endopolysaccharides, and the extracellular subfraction of low molecular weight metabolites isolated from the fungus C. unicolor.
Further investigation on the relationship between exposure to a nanomaterial, its effects and its physico-chemical properties, may provide insight into structure activity relationships and clues on the most appropriate dose metric prompting to describe toxicity.
Here, data from three continuously monitored life-cycle toxicity tests with C. elegans were used to parameterize DEBtox models from which a number of biologically meaningful parameters describing toxicity, including toxicokinetic and life-history associated parameters and physiological mode of action, were estimated.
LTS were (see Supplementary material, Table 3, which describes toxicities characterizing LTS in individual patients) G2-3 diarrhea-associated, 9 patients (69.2%), 8 LTS-ms and 1 LTS-ss; G3 mucositis associated with G3 erythema, 1; G3 stomatitis/mucositis and G2 asthenia, 1; G2 neutropenia for >2 weeks with G2 nausea, 1; and G3 asthenia, 1.
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