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Some of these interactions have been previously described to interact with efl-1 (T26A5.8 [5] and mat-3 [14].
This review summarizes the growing number of epigenetic modifying factors described to interact with lncRNAs in mouse and human, and then discusses the challenges that lay ahead in understanding lncRNAs as part of the intricate networks of epigenetic regulation.
DRIL1 was previously described to interact with Ubc9, the only known SUMO E2 conjugating enzyme [14].
In turn, EED was described to interact with HIV-1 matrix, integrase and Nef [27] [29].
Only two phosphatases, PP2Cdelta [54] and PP2A [55] have been described to interact with RSK.
Recently, the sialomucin PSGL-1 has been described to interact with CCL21 to facilitate the homing of T cells [15].
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None of these receptors were previously described to directly interact with folate and we did not identify any other known folate receptors.
PKCα has been described to directly interact with CAV1.
Components of the IFN signaling network have been described to directly interact with and to cooperatively induce target genes together with subunits of the NF- κB signaling network.
The slight activation of the canonical NF- κB pathway in our model may occur via a crosstalk with the non-canonical NF- κB pathway, because NIK has been described to also interact and phosphorylate IKK β, although IKK α is known as a preferential substrate for NIK.
Ena/Vasp and Clip-170 have been described to physically interact with the FH2 domain of Dia. - Although it has not been addressed, if and how binding of Ena/Vasp or Clip-170 interferes with nucleation and elongation and barbed end binding, it is attractive to speculate that binding to the FH2 domain may block sites important for the catalytic mechanism and suppress one or more of these activities.
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