Sentence examples for described to function as from inspiring English sources
Other putative substrates have been described to function as peptide and lipoprotein receptors, cellular adhesion molecules, proteases, and in intracellular protein trafficking.
The mechanism of nutrient sensing by transceptors seems to be conserved because permeases for sugars, amino acids, ammonium, nitrate, and sulfate have also been described to function as transceptors in other organisms.
The Presenilin gene encodes an eight to nine-pass transmembrane protein best described to function as the catalytic subunit of the γ-secretase multiprotein complex after an endoproteolytic processing, but also as a regulator of calcium flux in the ER.
Although inhibitor of apoptosis (IAP) proteins were initially described to function as endogenous caspase inhibitors, X-linked IAP (XIAP) but not cellular IAP1 (cIand) and cIAP2 possesses the critical residues for direct inactivation of caspases.
First, though described to function as both a transcriptional activator and repressor, ATF7IP is a particularly interesting candidate factor for a regulator of XCI because in its repressive context, it has been shown to mediate MBD1-dependent transcriptional silencing through the recruitment and catalytic activation of the histone H3K9 methyltransferase SETDB1 [ 29- 31].
Both the canonical LPxY as well as the LPxF variant found in Beclin 1 of Brugia malayi represent sequence motifs that have been described to function as binding sites for Nedd4/Rsp5-like Ub-isopeptide ligases in several proteins [ 24, 25].
ATF7IP was previously described to function not only as transcriptional repressor but also as transcriptional activator, as in addition to the repressive chromatin factors SETDB1 and MBD1, it was also found to interact and function with general transcription factors, RNA polymerase II, and the transcriptional activator SP1 [ 42, 43].
The inhibitory effect of 3BrPA on glycolysis has both been described to function through targeting of glyceraldehyde dehydrogenase as well as of the rate-limiting enzyme hexokinase, catalyzing the conversion of glucose to glucose-6-phosphate in the first step of the glycolytic reaction.
The Nurse Roadmap was described to primarily function as overarching guidelines for nursing sector bodies to divide and delineate programmatic initiatives in training and care delivery.
Simpson et al. described PR-A to function as a transcriptional inhibitor of ER [ 15].
Previously, the interpreter's role was to act as a translation machine providing accurate and neutral communication [ 52], but the role of the interpreter has also been questioned [ 22, 23] and described as complex and extended to function as advocacy and a bridge between cultures [ 53– 53].
