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Germline mutations in transcription factors, which are implicated in hematopoiesis in general or specifically in B-cell differentiation have recently been described to confer an inherited risk to pB-ALL with often reduced penetrance.
Gfi1 is a SNAG-domain-containing zinc-finger transcriptional repressor that was originally described to confer cytokine-independent growth in a T cell lymphoma line [11].
Antiviral effect was not affected by variants described to confer resistance.
To date, ∼100 NLRs in rice have been described to confer resistance to strains of M. oryzae, and 23 of these have been cloned (Liu et al., 2014).
Concerning the 13th and final clone, a mutation in codon 143 has been previously described to confer low resistance to rifampicin (R143W, [ 34]), but the mechanistic causes of resistance for this clone remain unclear.
In addition to the already known mutation L595S, a new mutation was detected in the UL97 region, namely the mutation H411Y which has been described to confer resistance to maribavir [ 15].
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So far the OSCP protein has been described as key to confer oligomycin sensitivity to the ATP synthase.
In this work, a catenary physiologically-based pharmacokinetic (PBPK) model is described to predict the pharmacokinetic benefit conferred by engineering mAbs for 'catch and release' binding.
have described its inability to confer azithromycin resistance, other authors have established a similar activity on hydrolysing erythromycin and azithromycin39.
In addition, several points of non-synonymous mutations in the gene encoding the trans-membrane voltage-gated sodium channel (kdr mutations) have been described and showed to confer resistance to pyrethroids and DDT [ 27, 29].
The well described apoAIMilano mutation appears to confer protection against atherosclerosis [111].
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