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We selected these genes because i) they have been previously shown to have a significant fold-change in our cDNA microarray analysis [18] of genes expressed in patients with DF versus DHF, compared to non-dengue (ND) patients, or ii) they have been described to be relevant for hemorrhagic symptoms of dengue by others in the literature [7] [10], [12], [17], [20].
Although NSP1 was recently described to be relevant for mycorrhization [ 34– 36], the extent of reduction of gene expression responses towards Myc-LCOs was unexpected.
It can also depend on local estrogen levels and intracellular conversion from androgen precursors, mechanisms described to be relevant in inflammation [ 27].
None of the SNPs especially those, who were previously described to be relevant for treatment efficacy, had a significant influence on LRC, PFS or OS in our cohort.
Especially a cross-talk between IL-32 and TNF has been described to be relevant in the pathogenesis of these diseases [ 15- 17].
Although miRNA 142 3p has been recently described to be relevant for DC, Bronte showed for the first time the in vivo effect of overexpression of this miRNA in bone marrow precursors during tumor growth.
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NAMPT has been described to be a relevant clinical biomarker in a series of inflammatory-related disorders and now our results suggest that NAMPT is an important actor in the pathology of these diseases.
In addition, several tumor markers have been described to be independently relevant for estimation of prognosis in terms of overall or progression-free survival in NSCLC patients [ 14].
Because the Wnt/β-catenin pathway has been described to be involved in relevant developmental and regenerative processes in the lung in general (Beers and Morrisey, 2011), as well as in lung injury and repair processes in particular (Flozak et al., 2010; Aumiller et al., 2013; Königshoff et al., 2009), we asked the question, are the newly identified proteins linked to Wnt/β-catenin signaling?
In biological systems, in which crowded environments slow down diffusion relative to reaction and phosphatase recruitment is often delayed, the effects we have described are likely to be relevant.
Items that seemed to fit the six subscales listed above were chosen, and these items were rewritten: (1) to conform to the scaling requirements of the survey (described below); (2) to be relevant to NHAs (i.e., face validity); and (3) to be relevant to the nursing home context (i.e., content validity).
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described to be neuroischemic
described to be favorable
described to be heterogeneous
described to be separate
described to be self-transmissible
described to be short
described to be good
described to be capable
described to be non-homologous
described to be important
described to be human
described to be up-regulated
described to be normal
described to be nonleukemogenic
described to be nephrotoxic
described to be moderate
described to be indistinguishable
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com